Image: Schistosoma mansoni genome assembly

Publications & Tools

Wannaporn Ittiprasert, Max F. Moescheid, Cristian Chaparro, Victoria H. Mann, Thomas Quack, Rutchanee Rodpai, André Miller, Prapakorn Wisitpongpun, Watunyoo Buakaew, Margaret Mentink-Kane, Sarah Schmid, Anastas Popratiloff, Christoph G. Grevelding, Christoph Grunau, Paul J. Brindley (2023).  Targeted insertion and reporter transgene activity at a gene safe harbor of the human blood fluke, Schistosoma mansoni. Cell Reports Methods Vol. 3, Issue 7, 100535, 24 July 2023, DOI:https://doi.org/10.1016/j.crmeth.2023.100535.

Kaethner M, Epping K, Bernthaler P, et al. Transforming growth factor-β signalling regulates protoscolex formation in the Echinococcus multilocularis metacestode. Frontiers in Cellular and Infection Microbiology. 2023 ;13:1153117. DOI: 10.3389/fcimb.2023.1153117. PMID: 37033489; PMCID: PMC10073696.

Akito Koike,Frank Becker,Peter Sennhenn,Jason Kim,Jenny Zhang,Stefan Hannus,Klaus Brehm (2022). Targeting Echinococcus multilocularis PIM kinase for improving anti-parasitic chemotherapy.  PLOS Neglected Tropical Diseases (accepted), 03 October 2022. https://doi.org/10.1371/journal.pntd.0010483.

Chaiyadet S, Tangkawattana S, Smout MJ, Ittiprasert W, Mann VH, Deenonpoe R, Arunsan P, Loukas A, Brindley PJ, Laha T. Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini. PLoS Pathog. 2022 Sep 22;18(9):e1010839. https://doi.org/10.1371/journal.ppat.1010839.

Quinzo, M.J., Perteguer, M.J., Brindley, P.J. et al. Transgenesis in parasitic helminths: a brief history and prospects for the future. Parasites Vectors 15, 110 (2022). https://doi.org/10.1186/s13071-022-05211-z.

Hulme BJ, Geyer KK, Forde-Thomas JE, Padalino G, Phillips DW, Ittiprasert W, Karinshak SE, Mann VH, Chalmers IW, Brindley PJ, Hokke CH, Hoffmann KF. Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production. PLoS Pathog. 2022 Jan 13;18(1):e1009828. doi: 10.1371/journal.ppat.1009828. Epub ahead of print. PMID: 35025955.

Wannaporn Ittiprasert, Chawalit Chatupheeraphat, Victoria H. Mann, Wenhui Li, André Miller, Taiwo Ogunbayo, Kenny Tran, S. Yousef N. Alrefaei, Margaret Mentink-Kane and Paul J. Brindley (2022). RNA-Guided AsCas12a- and SpCas9-Catalyzed Knockout and Homology Directed Repair of the Omega-1 Locus of the Human Blood Fluke, Schistosoma mansoni. Int. J. Mol. Sci. 2022, 23(2), 631; https://doi.org/10.3390/ijms23020631.

Rawlinson K, Reid AJ, Lu Z, Driguez P, Wawer A, Coghlan A, Sankaranarayanan G, Buddenborg SK, Diaz-Soria C, McCarthy C, Holroyd N, Sanders M, Hoffmann K, Wilcockson D, Rinaldi G, Berriman M. Daily rhythms in the transcriptomes of the human parasite Schistosoma mansoni. BMC Biology. 2021 Dec 2;19(1):255. doi: 10.1186/s12915-021-01189-9.

Kristin Stoll, Monika Bergmann, Markus Spiliotis, Klaus Brehm (2021). A MEKK1 â JNK mitogen activated kinase (MAPK) cascade module is active in Echinococcus multilocularis stem cells. PLOS Neglected Tropical Disease, Published: December 8, 2021, https://doi.org/10.1371/journal.pntd.0010027

Luviano N, Lopez M, Gawehns F, Chaparro C, Arimondo PB, Ivanovic S, David P, Verhoeven K, Cosseau C, Grunau C. The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor. Epigenetics Chromatin. 2021 Oct 26;14(1):48. doi: 10.1186/s13072-021-00422-7. PMID: 34702322; PMCID: PMC8549274.

Maria Stitz, Cristian Chaparro, Zhigang Lu, V. Janett Olzog, Christina E. Weinberg, Jochen Blom, Alexander Goesmann, Christoph Grunau and Christoph G. Grevelding (2021). Satellite-Like W-Elements: Repetitive, Transcribed, and Putative Mobile Genetic Factors with Potential Roles for Biology and Evolution of Schistosoma mansoni. Genome Biol Evol 13(10):evab204, 1 September 2021. doi: 10.1093/gbe/evab204.

Sarah K. Buddenborg, Alan Tracey, Duncan J. Berger, Zhigang Lu, Stephen R. Doyle, Beiyuan Fu, Fengtang Yang, Adam J. Reid, Faye H. Rodgers, Gabriel Rinaldi, Geetha Sankaranarayanan, Ulrike Böhme, Nancy Holroyd, Matthew Berriman. (2021, Pre-print). Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system.  bioRxiv 2021.08.13.456314; doi: https://doi.org/10.1101/2021.08.13.456314.

Gilda Padalino, Nelly El-Sakkary, Lawrence J. Liu, Chenxi Liu, Danielle S. G. Harte, Rachel E. Barnes, Edward Sayers, Josephine Forde-Thomas, Helen Whiteland, Marcella Bassetto, Salvatore Ferla, George Johnson, Arwyn T. Jones, Conor R. Caffrey, Iain Chalmers, Andrea Brancale, Karl F. Hoffmann (2021). Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. European Journal of Medicinal Chemistry, Vol. 226, 113823, 15 December 2021. doi: https://doi.org/10.1016/j.ejmech.2021.113823.

Herz, M., Brehm, K. (2021). Serotonin stimulates Echinococcus multilocularis larval development. Parasites Vectors 14, 14 (2021). https://doi.org/10.1186/s13071-020-04533-0.

Sankaranarayanan G, Berriman M, Rinaldi G. (2021) An uneven race: genome editing for parasitic worms. Nat Rev Microbiol. 2021 Oct;19(10):621. doi: 10.1038/s41579-021-00625-5. PMID: 34404952.

Zhigang Lu, Geetha Sankaranarayanan, Kate A. Rawlinson, Victoria Offord, Paul J. Brindley, Matthew Berriman, Gabriel Rinaldi (2021). The Transcriptome of Schistosoma mansoni Developing Eggs Reveals Key Mediators in Pathogenesis and Life Cycle Propagation. Frontiers in Tropical Diseases, Vol. 2, 18 August 2021, ISSN 2673-7515. DOI: 10.3389/fitd.2021.713123.

Natalia Macchiaroli, Matías Preza, Matías Gastón Pérez, Laura Kamenetzky, Marcela Cucher, Uriel Koziol, Estela Castillo, Matthew Berriman, Klaus Brehm , Mara Cecilia Rosenzvit (2021). Expression profiling of Echinococcus multilocularis miRNAs throughout metacestode development in vitro. PLOS Neglected Tropical Diseases, 2021 Mar 22;15(3):e0009297. doi: 10.1371/journal.pntd.0009297. eCollection 2021 Mar.

Grimm J, Krickl J, Beck A, Nell J, Bergmann M, Tappe D, Grüner B, Barth TF, Brehm K. (2021). Establishing and evaluation of a polymerase chain reaction for the detection of Echinococcus multilocularis in human tissue. PLoS Negl Trop Dis. 2021 Feb 25;15(2):e0009155. doi: 10.1371/journal.pntd.0009155. PMID: 33630840; PMCID: PMC7906421.

Holly M. Craven, Riccardo Bonsignore, Vasilis Lenis,Nicolo Santi, Daniel Berrar, Martin Swain, Helen Whiteland, Angela Casini, Karl F. Hoffmann (2021). Identifying and validating the presence of Guanine Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni. PLOS Neglected Tropical Diseases, February 18, 2021, https://doi.org/10.1371/journal.pntd.0008770.

Augusto RdC, Rey O, Cosseau C et al. A simple ATAC-seq protocol for population epigenetics [version 2; peer review: 2 approved]. Wellcome Open Res 2021, 5:121. https://doi.org/10.12688/wellcomeopenres.15552.2.

Takaki KK, Roca FJ, Schramm G, Wilbers RHP, Ittiprasert W, Brindley PJ, Rinaldi G, Berriman M, Ramakrishnan L, Pagán AJ. (2021) Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response. PLoS Neglected Tropical Diseases, 19 January 2021,19;15(1):e0008814. doi: 10.1371/journal.pntd.0008814PMID: 33465071.

You H, Mayer JU, Johnston RL, Sivakumaran H, Ranasinghe S, Rivera V, Kondrashova O, Koufariotis LT, Du X, Driguez P, French JD, Waddell N, Duke MG, Ittiprasert W, Mann VH, Brindley PJ, Jones MK, McManus DP. (2021) CRISPR/Cas9-mediated genome editing of Schistosoma mansoni acetylcholinesterase. FASEB Journal, 18 December 2020, 35(1):e21205.

Diaz Soria, C.L., Lee, J., Chong, T. et al. Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni. Nat Commun 11, 6411 (2020). https://doi.org/10.1038/s41467-020-20092-5

Website generated in relation to Soria et al. 2020 (article above): https://www.schistosomulacellatlas.org

Database generated by Collins Lab for the visualization of scRNAseq data: Collinslab.org/schistocyte

María Eugenia Ancarola, Gabriel Lichtenstein, Johannes Herbig, Nancy Holroyd, Mara Mariconti, Enrico Brunetti, Matthew Berriman, Krystyna Albrecht, Antonio Marcilla, Mara Cecilia Rosenzvit, Laura Kamenetzky, Klaus Brehm, Marcela Cucher (2020). Extracellular non-coding RNA signatures of the metacestode stage of Echinococcus multilocularis. PLOS Neglected Tropical Diseases, 30 November 2020, https://doi.org/10.1371/journal.pntd.0008890.

Fernanda Sales Coelho, Rutchanee Rodpai, André Miller, Shannon E. Karinshak, Victoria H. Mann, Omar dos Santos Carvalho, Roberta Lima Caldeira, Marina de Moraes Mourão, Paul J. Brindley and Wannaporn Ittiprasert (2020). Diminished adherence of Biomphalaria glabrata embryonic cell line to sporocysts of Schistosoma mansoni following programmed knockout of the allograft inflammatory factor. Parasites Vectors 13, 511 (2020). https://doi.org/10.1186/s13071-020-04384-9. 

Gilda Padalino 1, Iain W Chalmers 1, Andrea Brancale 2, Karl F Hoffmann 1. Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities.  Wellcome Open Res. 2020 Nov 13;5:169.doi: 10.12688/wellcomeopenres.16069.2.eCollection 2020.

George Wendt, Lu Zhao, Rui Chen, Chenxi Liu, Anthony J. O’Donoghue, Conor R. Caffrey, Michael L. Reese, James J. Collins III (2020). A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding. Science 25 Sep 2020, Vol. 369, Issue 6511, pp. 1644-1649, DOI: 10.1126/science.abb7709.

Jipeng Wang, Carlos Paz, Gilda Padalino, Avril Coghlan, Zhigang Lu, Irina Gradinaru, Julie Collins, Matthew Berriman, Karl F. Hoffmann, James J. Collins III (2020). Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni. Science 25 Sep 2020, Vol. 369, Issue 6511, pp. 1649-1653, DOI: 10.1126/science.abb7699.

Wangwiwatsin A, Protasio AV, Wilson S, Owusu C, Holroyd NE, Sanders M, Keane J, Doenhoff M, Rinaldi G, Berriman M. Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development. PLoS Negl Trop Dis, Published: May 6, 2020, https://doi.org/10.1371/journal.pntd.0007743

Weth, O., Haeberlein, S., Haimann, M., Zhang, Y., Grevelding, C.G. (2020) Towards deorphanizing G protein-coupled receptors of Schistosoma mansoni using the MALAR yeast two-hybrid system. Parasitology 147(8), 865-873, DOI: 10.1017/S0031182019001756

Sankaranarayanan G, Coghlan A, Driguez P et al. Large CRISPR-Cas-induced deletions in the oxamniquine resistance locus of the human parasite Schistosoma mansoni [version 2; peer review: 4 approved]Wellcome Open Res 2021, 5:178 (https://doi.org/10.12688/wellcomeopenres.16031.2)

Michaela Herz and Klaus Breham (2019). Evidence for densovirus integrations into tapeworm genomes. Parasites and Vectors 2019 12:560, https://doi.org/10.1186/s13071-019-3820-1. 

Matıas Gasto Perez, Markus Spiliotis, Natalia Rego, Natalia Macchiaroli, Laura Kamenetzky, Nancy Holroyd, Marcela Alejandra Cucher, Klaus Brehm, Mara Cecilia Rosenzvit (2019). Deciphering the role of miR-71 in Echinococcus multilocularis early development in vitro. PLOS Neglected Tropical Diseases. PLoS Negl Trop Dis 13(12): e0007932. https://doi.org/10.1371/journal.pntd.0007932.

Kezia C. L. Whatley, Gilda Padalino, Helen Whiteland, Kathrin K. Geyer, Benjamin J. Hulme, Iain W. Chalmers, Josephine Forde-Thomas, Salvatore Ferla, Andrea Brancale and Karl F. Hoffmann (2019). The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets. PLOS Neglected Tropical Diseases, 15 November 2019, DOI: https://doi.org/10.1371/journal.pntd.0007693.

Lu, Z., Spaenig, S., Weth, O., Grevelding C.G. (2019) Males, the Wrongly Neglected Partners of the Biologically Unprecedented Male-Female Interaction of Schistosomes. Front. Genet. (in press) doi: 10.3389/fgene.2019.00796.

Augusto R..C., Cosseau C., Grunau C. (2019) Histone Methylome of the Human Parasite Schistosoma Mansoni. In: Jurga S., Barciszewski J. (eds) The DNA, RNA, and Histone Methylomes. RNA Technologies. Springer, Cham. https://doi.org/10.1007/978-3-030-14792-1_24.

Ronaldo De Carvalho Augusto, David Duval, Christoph Grunau. (2019). Effects of the environment on developmental plasticity and infection success of Schistosoma parasites – an epigenetic perspective. Frontiers in Microbiology, Microbial Immunology, 09 July 2019, https://doi.org/10.3389/fmicb.2019.01475.

Wang J, Chen R, Collins JJ 3rd (2019). Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni. PLoS Biol. 2019 May 8;17(5):e3000254. doi: 10.1371/journal.pbio.3000254. eCollection 2019 May. PMID: 31067225.

Sabine Forster, Uriel Koziol, Tina Schafer, Raphael Duvoisin, Katia Cailliau, Mathieu Vanderstraete, Colette Dissous, Klaus Brehm (2019). The role of fibroblast growth factor signalling in Echinococcus multilocularis development and host-parasite interaction. PLOS Neglected Tropical Diseases, 08 March 2019, https://doi.org/10.1371/journal.pntd.0006959. 

Arunsan P, Ittiprasert W, Smout MJ, Cochran CJ, Mann VH, Chaiyadet S, Karinshak SE, Sripa B, Young ND, Sotillo J, Loukas A, Brindley PJ, Laha T. (2019). Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity. Elife. 2019 Jan 15;8. pii: e41463. doi: 10.7554/eLife.41463.

Wannaporn Ittiprasert, Victoria H Mann, Shannon E Karinshak, Avril Coghlan, Gabriel Rinaldi, Geetha Sankaranarayanan, Apisit Chaidee, Toshihiko Tanno, Chutima KumKhaek, Pannathee Prangtaworn, Margaret M Mentink-Kane, Christina J Cochran, Patrick Driguez, Nancy Holroyd, Alan Tracey, Rutchannee Rodpai, Bart Everts, Cornelis H Hokke, Karl F Hoffmann, Matthew Berriman, Paul J Brindley (2019). Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni. eLife doi: 10.7554/eLife.41337.

Jipeng WangRui ChenJames Collins III (2018). in vitro egg production by the human parasite Schistosoma mansoni. bioRxiv. doi: https://doi.org/10.1101/411397 

Patphicha Arunsan, Wannaporn Ittiprasert, Michael J Smout, Christina J Cochran, Victoria H Mann, Sujittra Chaiyadet, Shannon E Karinshak, Banchob Sripa, Neil D Young, Javier Sotillo, Alex Loukas, Paul J Brindley, Thewarach Laha (2018). Programmed mutation of liver fluke granulin using CRISPR/Cas9 attenuates virulence of infection-induced hepatobiliary morbidity. bioRxiv. doi: https://doi.org/10.1101/386219

Gilda Padalino, Salvatore Ferla, Andrea Brancale, Iain W. Chalmers, Karl F. Hoffmann (2018). Erratum to 'Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni'. International Journal for Parasitology: Drugs and Resistance. https://doi.org/10.1016/j.ijpddr.2019.07.001.

Gilda Padalino, Salvatore Ferla, Andrea Brancale, Iain W. Chalmers, Karl F. Hoffmann (2018). Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni. International Journal for Parasitology: Drugs and Resistance. https://doi.org/10.1016/j.ijpddr.2018.10.005.

Picard MAL, Cosseau C, Ferré S, Quack T, Grevelding CG, Couté Y, Vicoso B. (2018). Evolution of gene dosage on the Z-chromosome of schistosome parasites. eLIFE 2018 Jul 25;7. pii: e35684. doi: 10.7554/eLife.35684

Kathrin K. Geyer, Sabrina E. Munshi, Helen L. Whiteland, Narcis Fernandez-Fuentes, Dylan W. Phillips, Karl F. Hoffmann (2018). Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni. PLOS Pathogens, 28 June 2018. https://doi.org/10.1371/journal.ppat.1007107 

Yan, H. B., Smout, M. J., Ju, C., Folley, A. E., Skinner, D. E., Mann, V. H., Loukas, A., Hu, W., Brindley, P. J., & Rinaldi, G. (2018). Developmental Sensitivity in Schistosoma mansoni to Puromycin To Establish Drug Selection of Transgenic Schistosomes. Antimicrobial agents and chemotherapy, 62(8), e02568-17. doi: 10.1128/AAC.02568-17. PMID: 29760143; PMCID: PMC6105839. 

David Roquis, Aaron Taudt, Kathrin K. Geyer, Gilda Padalino, Karl F. Hoffmann, Nancy Holroyd, Matt Berriman, Benoît Aliaga, Cristian Chaparro, Christoph Grunau, Ronaldo de Carvalho Augusto (2018). Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni. PLOS Pathogens 14(5):e1007066 21 May 2018, https://doi.org/10.1371/journal.ppat.1007066. 

Wendt G.R., Collins J.N., Pei J., Pearson M.S., Bennett H.M., Loukas A., Berriman M., Grishin N.V., Collins J.J.  (2018). Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni. Elife 2018 Mar 20;7. pii: e33221. doi: 10.7554/eLife.33221.

Palevich N., Britton C., Kamenetzky L., Mitreva M., de Moraes Mourão M., Bennuru S., Quack T., Lopes L., Scholte S., Tyagi R., Slatko BE. (2018). Tackling Hypotheticals in Helminth Genomes. The International Molecular Helminthology Annotation Network (IMHAN), Molecular Helminthology - An Integrated Approach, 19-22 March 2017, Cape Cod, MA, USA. Trends in Parasitology, 2018 Mar;34(3),179–83.

Grevelding, C.G., Langner, S., Dissous, C. (2018) Kinases: Molecular Stage Directors for Schistosome Development and Differentiation. Trends in Parasitology 34(3), 246-260.

Mouahid G., Rognon A., de Carvalho Augusto R., Driguez P., Geyer K., Karinshak S., Luviano N., Mann V., Quack T., Rawlinson K., Wendt G., Grunau C., Moné H. (2018). Transplantation of schistosome sporocysts between host snails: A video guide. Wellcome Open Res 2018, 3:3 (doi: 10.12688/wellcomeopenres.13488.1).

            Video 1: Technique de transplantation microchirurgicale de sporocystes de schistosomes.

            http://doi.org/10.5281/zenodo.1116997 (Mouahid et al., 2017a)

            Video 2: Technique of microsurgical transplantation of schistosomes sporocysts.

            http://doi.org/10.5281/zenodo.1117007 (Mouahid et al., 2017b)

            Video 3: Técnica de trasplantación microquirúrgica de esporocistos de Schistosoma.

            http://doi.org/10.5281/zenodo.1117009 (Mouahid et al., 2017c)

            Video 4: Técnica microcirúrgica de transplante de esporocistos de esquistossomas.

            http://doi.org/10.5281/zenodo.1117011 (Mouahid et al., 2017d)

            Video 5: Manufacture of tools for microsurgical transplantation of schistosoma sporocysts.

            http://doi.org/10.5281/zenodo.1117017 (Mouahid et al., 2017e)

Hahnel S, Wheeler N, Lu Z, Wangwiwatsin A, McVeigh P, Maule A, Berriman M, Day T, Ribeiro P, Grevelding CG. (2018). Tissue-specific transcriptome analyses provide new insights into GPCR signalling in adult Schistosoma mansoni. PLOS Pathogens Jan 2018, doi.org/10.1371/journal.ppat.1006718.

Avril Coghlan, Makedonka Mitreva, Matthew Berriman (2018). International Helminth Genomes Consortium. Comparative genomics of the major parasitic worms. Nat Genet 51, 163–174 (2019). https://doi.org/10.1038/s41588-018-0262-1.

Lu, Z., Sessler, F., Holroyd, N., Hahnel, S., Quack, T., Berriman, M., Grevelding, C.G. (2017). A gene expression atlas of adult Schistosoma mansoni and their gonads. Scientific Data 4, 170118 , DOI:10.1038/sdata.2017.118.

Hahnel, S., Parker-Manuel, R., Dissous, C., Cailliau, K., Grevelding, C.G. (2017). First characterization of SmOPG1, a novel protein involved in gonad-associated processes in Schistosoma mansoni. Molecular and Biochemical Parasitology 213, 22–25.

Augusto R. C., Tetreau G., Chan P., Walet-Balieu M. L., Mello-Silva C. C., Santos C. P., Grunau C. (2017). Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites. PLoS Negl Trop Dis Jul 28;11(7): e0005789. doi: 10.1371/journal.pntd.0005789.

Blohm A.S., Mäder P., Quack T., Lu Z., Hahnel S., Schlitzer M., Grevelding C. G. (2016). Derivatives of biarylalkyl carboxylic acid induce pleiotropic phenotypes in adult Schistosoma mansoni in vitro. Parasitology Research 2016 May 26. doi 10.1007/s00436-016-5146-7.

Collins, J.N.R., Collins, J.J., III 2016. Tissue Degeneration following Loss of Schistosoma mansoni cbp1 Is Associated with Increased Stem Cell Proliferation and Parasite Death in vivo. PLoS Pathog 12(11): e1005963.

Cosseau C, Wolkenhauer O, Padalino G, Geyer KK, Hoffmann KF and Grunau C (2016). (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach. Trends in parasitology 2016 PUBMED: 28040375; DOI: 10.1016/j.pt.2016.12.002

Grevelding, C.G., Hahnel, S., Lu, Z. (2016). Ova and oogenesis in Schistosoma. In: Schistosoma. Edited by B. G. M. Jamieson; CRC Press (Taylor and Francis) (in press)

Lu Z., Sessler F., Holroyd N., Hahnel S., Quack T., Berriman M., Grevelding C. G. (2016). Schistosome sex matters: a deep view into gonad-specific and pairing-dependent transcriptomes reveals a complex gender interplay. Scientific Reports 6, Article number: 31150 (2016), doi:10.1038/srep31150.

Suttiprapa S, Rinaldi G, Tsai IJ, Mann VH, Dubrovsky L et al. (2016). HIV-1 Integrates Widely throughout the Genome of the Human Blood Fluke Schistosoma mansoni. PLoS pathogens 2016;12;10;e1005931, PUBMED: 27764257; PMC: 5072744; DOI: 10.1371/journal.ppat.1005931.

Wang J. Collins J. J. III (2016). Identification of new markers for the Schistosoma mansoni vitelline lineage. International Journal for Parasitology 2016 Jun;46(7):405-10. doi: 10.1016/j.ijpara.2016.03.004.

Wendt G. R., Collins J. J. III (2016). Schistosomiasis as a disease of stem cells. Curr Opin Genet Dev. 2016 Jul 5;40:95-102. doi: 10.1016/j.gde.2016.06.010.

Hoffmann KF, Brindley PJ and Berriman M (2014). Medicine. Halting harmful helminths. Science (New York, N.Y.) 2014; 346; 6206; 168-9, PUBMED: 25301604; doi: 10.1126/science.1261139.

Figshare, published by C Grevelding: https://doi.org/10.6084/m9.figshare.4868093.v2
  https://doi.org/10.6084/m9.figshare.4884290.v2
Searchable web-interface, programmed by Z Lu: http://schisto.xyz/geneexp